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Release 14.1
Pathogen: Plasmodium falciparum

Plasmodium species have a complex life cycle, shared between a mosquito vector and a vertebrate host. After infection through a mosquito bite, sporozoites migrate to the liver and undergo an initial proliferation phase in hepatocytes. After differentiation, merozoites are released into the blood where they invade and multiply within red blood cells. Some merozoites differentiate into gametocytes, which can be ingested during a subsequent blood meal and undergo sexual reproduction in the mosquito. While erythrocytes provide the parasite sanctuary from the immune system, the spleen eventually detects and destroys the increasingly inflexible erythrocytes. To prevent destruction by the spleen, the parasite exports adhesive PfEMP1 proteins to the red blood cell surface, causing red blood cells to form rosettes and adhere to capillary walls, disrupting circulation and triggering the symptoms of severe malaria.

Name: Plasmodium falciparum
Pathogen type: Protist
Description: Protist parasite causes the most severe form of malaria in humans
Lineage: Eukaryota » Alveolata » Apicomplexa » Aconoidasida » Haemosporida » Plasmodium » Plasmodium (Laverania) » Plasmodium falciparum
Distribution: Sub-Saharan Africa, South America, South and Southeast Asia, the Middle East
Life cycle: Transferred from mosquito to human during blood meal. Migrates to the liver, then to erythrocytes, and gametocytes are transferred following a subsequent blood meal.
Chromosomes: 14
GC content: 23.80
Genome: http://www.plasmodb.org/plasmo/home.jsp
http://www.broad.mit.edu/annotation/genome/plasmodium_falciparum_spp/MultiHome.html
KEGG: pfa pfd pfh
Pathway: pfa05144

References

Last modified: 1? 14, 2013



Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan
System last updated Thu, January 24, 2013 14:25:29 JST / SVN revision: 1054
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