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Release 14.1
Last modified: 1? 14, 2013
Pathogen: Borrelia burgdorferi

Borrelia burgdorferi
Borrelia burgdorferi is a Gram-negative spirochete responsible for Lyme disease.

Name: Borrelia burgdorferi
Pathogen type: Bacteria
Description: Gram-negative spirochete responsible for Lyme disease
Lineage: Bacteria » Spirochaetes » Spirochaetia » Spirochaetales » Spirochaetaceae » Borrelia » Borrelia burgdorferi group » Borrelia burgdorferi
Life cycle: infect vectors during blood meal and then migrate to salivary glands
Chromosomes: linear chromosomes
GC content: 29.75
Genes: 1780
Proteins: 851
Bases: 1519856: 910725 bp (chromosomes) + 533000 bp (plasmids)
Genome: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=gbb
Size: 10-30 microns long, 0.3 microns wide
Morphology: irregular spirals, two-membranes
Gram-staining: Gram-negative
Aerobic: false
Plasmids: 17+ circular and linear plasmids
Appendages: 2 flagella
KEGG: bbu

References
Norris SJ. 2006. Antigenic variation with a twist--the Borrelia story. Molecular microbiology 60:1319-22. (16796669)
Lawson CL, Yung BH, Barbour AG, Zückert WR. 2006. Crystal structure of neurotropism-associated variable surface protein 1 (Vsp1) of Borrelia turicatae. Journal of bacteriology 188:4522-30. (16740958)
Nordstrand A, Barbour AG, Bergström S. 2000. Borrelia pathogenesis research in the post-genomic and post-vaccine era. Current opinion in microbiology 3:86-92. (10679423)
Zhang JR, Norris SJ. 1998. Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion. Infection and immunity 66:3698-704. (9673251)
Tourand Y, Bankhead T, Wilson SL, Putteet-Driver AD, Barbour AG, Byram R, Rosa PA, Chaconas G. 2006. Differential telomere processing by Borrelia telomere resolvases in vitro but not in vivo. Journal of bacteriology 188:7378-86. (16936037)
Dai Q, Restrepo BI, Porcella SF, Raffel SJ, Schwan TG, Barbour AG. 2006. Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids. Molecular microbiology 60:1329-43. (16796672)

Last modified: 1? 14, 2013



Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan
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