Babesia bovis is a tick-borne apicomplexan parasite responsible for babesiosis,
an economically important disease of cattle, and an emerging human zoonosis.
Unlike relatives Plasmodium and Theleria, infection begins directly with erythrocyte invasion,
but symptoms are similar to malaria, including anemia, sequestration, and neurological effects.
References
Brayton KA, Lau AO, Herndon DR, Hannick L, Kappmeyer LS, Berens SJ, Bidwell SL, Brown WC, Crabtree J, Fadrosh D, Feldblum T, Forberger HA, Haas BJ, Howell JM, Khouri H, Koo H, Mann DJ, Norimine J, Paulsen IT, Radune D, Ren Q, Smith RK, Suarez CE, White O, Wortman JR, Knowles DP, McElwain TF, Nene VM. 2007. Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa. PLoS pathogens 3:1401-13. (17953480)
de Vries E, Corton C, Harris B, Cornelissen AW, Berriman M. 2006. Expressed sequence tag (EST) analysis of the erythrocytic stages of Babesia bovis. Veterinary parasitology 138:61-74. (16530971)
Allred DR, Al-Khedery B. 2004. Antigenic variation and cytoadhesion in Babesia bovis and Plasmodium falciparum: different logics achieve the same goal. Molecular and biochemical parasitology 134:27-35. (14747140)
Al-Khedery B, Allred DR. 2006. Antigenic variation in Babesia bovis occurs through segmental gene conversion of the ves multigene family, within a bidirectional locus of active transcription. Molecular microbiology 59:402-14. (16390438)
Allred DR. 2003. Babesiosis: persistence in the face of adversity. Trends in parasitology 19:51-5. (12586467)
Allred DR. 1998. Antigenic variation in Babesia bovis: how similar is it to that in Plasmodium falciparum? Annals of tropical medicine and parasitology 92:461-72. (9683897)
Dzikowski R, Deitsch K. 2006. Antigenic variation by protozoan parasites: insights from Babesia bovis. Molecular microbiology 59:364-6. (16390434)
Allred DR, Al-Khedery B. 2006. Antigenic variation as an exploitable weakness of babesial parasites. Veterinary parasitology 138:50-60. (16517078)